The official PDF download is available for purchase from CLSI and its authorized resellers. Below is a table of official sources where you can legally purchase and download the PDF, with direct links.
The CLSI M22-A3 document provides explicit guidance for both manufacturers and user laboratories regarding the quality control testing of commercially prepared microbiological culture media. Published as a third edition, this consensus standard establishes benchmarks to ensure that the media used to isolate and identify pathogens performs reliably. The Problem M22-A3 Solves clsi m22a3 pdf link
Keep a robust collection of American Type Culture Collection (ATCC) strains ready for testing non-exempt media. The official PDF download is available for purchase
Many university libraries, hospital networks, and public health departments hold institutional subscriptions to the CLSI eChalign database, allowing personnel to download the PDF for free legally. A Note on Unofficial PDF Downloads Published as a third edition, this consensus standard
Document every type of culture media used in your facility.
In the realm of clinical microbiology, the reliability of diagnostic results relies heavily on the quality of the media used to grow microorganisms. The provides essential guidelines to ensure this quality. One of the cornerstone documents for laboratories sourcing pre-made media is CLSI M22-A3 , titled "Quality Control for Commercially Prepared Microbiological Culture Media; Approved Standard—Third Edition".
Media types that are highly selective, complex, or prone to degradation (e.g., Campylobacter agar, chocolate agar for specific fastidious organisms, or selective broths). The laboratory must test these batches using control organisms before releasing them for patient testing. Impact on Laboratory Accreditations
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